Role of Age and Sex in Chronic Thyroiditis in Rats Fed 3'-Methyl-4-Dimethylaminoazobenzene

Author:

Reuber M. D.1,Glover E. L.1

Affiliation:

1. Laboratory of Biology, National Cancer Institute, Bethesda, Md., and Department of Biology, Montgomery College, Takoma Park, Md.

Abstract

Inbred male and female Buffalo strain rats were started at 4, 8, 12, 24, or 52 weeks of age on 0.06% 3'-methyl-4-dimethylaminoazobenzene in a low-protein, choline-deficient diet. Eight-week-old males and females were the most susceptible to the development of chronic thyroiditis, but females were more susceptible than the males. Female rats of other ages developed a slightly higher incidence of thyroiditis than the male rats, the difference being most noticeable for rats 12 weeks old.

Publisher

SAGE Publications

Subject

General Veterinary

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Lymphocytic Thyroiditis, Rat;Endocrine System;1996

2. The Endocrine Glands;Atlas of Experimental Toxicological Pathology;1987

3. Lymphocytic Thyroiditis, Rat;Endocrine System;1983

4. The Effect of Gonadectomy on the Sex-Related Expression of Autoimmune Thyroiditis in Thymectomized and Irradiated Rats;American Journal of Reproductive Immunology;1981-12

5. Rat Lymphocytic Thyroiditis Associated with Ingestion of an Immunosuppressive Compound;Veterinary Pathology;1979-11

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