Untersuchungen zur Pathomorphologie und Pathogenese der Aujeszkyschen Krankheit

Abstract

Lumbo-intramuscular or naso-oral infection of 15 rabbits with Aujeszky's virus consistently produced alterations in the nerve cells of the spinal ganglia, the spinal nerve roots and the spinal cord, viz. nuclear inclusions of Cowdry types A and B. Lumbar infection produced neural lesions extending continuously from the site of infection via the spinal nerve roots and spinal ganglia as far as the dorsal and ventral nuclear regions of the spinal cord. The viral lesions following nasooral infection involved electively the sympathetic centers of the spinal cord with severe alterations of the sympathetic trunk ganglia. Despite this demonstration of viral propagation along neural routes, one should not disregard the possibility of hematogenous-lymphogenic propagation.