Ultrastructural Lesions of Pyridoxine Toxicity in Beagle Dogs-Reference-Cited by-同舟云学术

Ultrastructural Lesions of Pyridoxine Toxicity in Beagle Dogs

Published:1981-11 Issue:6 Volume:18 Page:769-777
ISSN:0300-9858
Container-title:Veterinary Pathology
language:en
Short-container-title:Vet Pathol

Author:

Hoover D. M.¹,Carlton W. W.¹,Henrikson C. K.¹

Affiliation:

1. Department of Veterinary Microbiology, Pathology and Public Health and Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, Ind.

Abstract

Three adult Beagle dogs given pyridoxine hydrochloride orally at a dose of 150 mg/kg body weight/day for about 100 days developed ataxia and had spastic, dysmetric leg movements. Ultrastructural alterations in the dorsal funiculus of the spinal cord were degeneration and loss of axons and myelin, and secondary changes of the myelin sheaths. Possible pathogenic mechanisms of pyridoxine neurotoxicity are discussed.

Publisher

SAGE Publications

Subject

General Veterinary

Link

http://journals.sagepub.com/doi/pdf/10.1177/030098588101800607

Reference18 articles.

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3. High Pyridoxine Diet in the Rat: Possible Implications for Megavitamin Therapy

4. Effect of pyridoxal administration on the contents of pyridoxal phosphate and .GAMMA.-aminobutyric acid in mouse brain.

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