Pathogenesis of Experimental Bovine Mycotic Placentitis Produced by Aspergillus fumigatus

Abstract

Eleven heifers were inoculated intravenously with a suspension of 1 × 108 conidia of Aspergillus fumigatus at 169 or 170 days after artificial insemination. These principals were killed at 4, 7, or 14 days after inoculation or thereafter when abortion occurred. Four other heifers served as controls. Mycotic placentitis was not found at 4 days after inoculation. In principals killed at 7 and 14 days, 24% of placentomes had lesions of mycotic placentitis. Heifers that aborted had necrotizing lesions in approximately 90% of placentomes as well as extensive involvement of the interplacentomal area. A theory for the spread of the mycosis in the placenta is presented.