3-Methylindole-Induced Nasal Mucosal Damage in Mice-Reference-Cited by-同舟云学术

3-Methylindole-Induced Nasal Mucosal Damage in Mice

Published:1987-09 Issue:5 Volume:24 Page:400-403
ISSN:0300-9858
Container-title:Veterinary Pathology
language:en
Short-container-title:Vet Pathol

Author:

Turk M. A. M.¹,Henk W. G.¹,Flory W.²

Affiliation:

1. Departments of Veterinary Pathology, Veterinary Anatomy and Fine Structure, and Veterinary Physiology, Pharmacology and Toxicology, Louisiana State University, Baton Rouge, LA

2. Veterinary Medical Diagnostic Laboratory and the Department of Veterinary Pathology, University of Missouri, Columbia, MO

Abstract

3-Methylindole (3MI) damages nasal olfactory epithelium in mice. Lesions were studied histologically from 30 minutes to 28 days after intraperitoneal injection of 400 mg 3MI/kg. Cellular swelling was apparent in olfactory epithelium by 6 hours after injection of 3MI, while respiratory epithelium was normal. Necrosis of olfactory epithelium and subepithelial glands was diffuse by 48 hours. Subsequent ulceration resulted in epithelial hyperplasia, squamous metaplasia, fibroplasia, and ossification. Partially occlusive intranasal fibrous and osseous tissue persisted through 28 days after 3MI injection.

Publisher

SAGE Publications

Subject

General Veterinary

Link

http://journals.sagepub.com/doi/pdf/10.1177/030098588702400506

Reference25 articles.

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