Multiple Osteomas in Mice

Author:

Höger H.1,Gialamas J.1,Jelinek F.2

Affiliation:

1. Research Institute for Laboratory Animal Breeding, University of Vienna, Himberg, Austria

2. Hlava Institute of Pathology, Faculty of Medicine, Charles University of Prague, Prague, Czech Republic

Abstract

Osteomas (dense compact neoplasms of mature bone tissue) are rare in nearly all strains and stocks of mice. Of 224 Him: OF1 mice maintained until natural death or until terminally ill. 116 (51.8%) had one or more osteomas. Osteomas had a predilection for the skull and the larger bones of the limbs. Plasma alkaline phosphatase concentrations were elevated significantly in osteoma-bearing mice (446 ± 153 U/liter versus 206 ± 65 U/liter in age-matched controls without osteomas). Only very large osteomas resulted in clinical signs, and longevity was not shortened. Histologic examination showed clearly separated dense bony tissue irregularly arranged and forming a mosaic pattern, with distinct cement lines and medullary spaces filled with fibroreticular connective tissue. Electron microscopic examination revealed virus-like structures in osteoblasts, osteocytes, and fibroblasts and in the place of remnants of necrotic cells.

Publisher

SAGE Publications

Subject

General Veterinary

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