Acute Pathological Effects of Inorganic Mercury and Copper in Gills of Rainbow Trout

Abstract

Lesions induced in the gills of rainbow trout (Salmo gairdneri) by exposure to acutely lethal aqueous concentrations of inorganic mercury and copper were examined by light and electron microscopy. Lesions were most severe during the first 48 hours of exposure to the metals and were characterized primarily by apoptosis of lamellar epithelial cells and lamellar fusion. The latter process occurred either by simple apposition of adjacent lamellae to each other or through epithelial hypertrophy and hyperplasia. Except for hypertrophy of and increased number of primary lysosomes in lamellar epithelial cells of animals exposed to mercury, branchial lesions were not prominent in fish collected between 48 and 96 hours. The branchial lesions observed in this study are compared with pathological processes occurring in mammals.