L-Ascorbate protects rat hepatocytes against sodium arsenite—induced cytotoxicity and oxidative damage-Reference-Cited by-同舟云学术

L-Ascorbate protects rat hepatocytes against sodium arsenite—induced cytotoxicity and oxidative damage

Published:2009-12-22 Issue:2 Volume:29 Page:103-111
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Asit Kumar Bera ¹,Rana Tanmoy²,Das Subhashree²,Bandyopadhyay Subhasish²,Bhattacharya Debasis²,Pan Diganta²,De Sumanta²,Subrata Kumar Das ²

Affiliation:

1. Indian Veterinary Research Institute, Eastern Regional Station, Kolkata, India,

2. Indian Veterinary Research Institute, Eastern Regional Station, Kolkata, India

Abstract

Sodium arsenite—exposed hepatocytes of rat showed higher production of nitric oxide (NO) and increased lipid peroxidation (LPO) level vis-a-vis activity of superoxide dismutase (SOD) and catalase (CAT) were significantly lowered. Subsequently, the cell proliferation index (CPI) and cell viability were also reduced. Treatment with L-ascorbate was found effective in normalizing the arsenic-induced alteration of SOD and CAT activity and LPO level in rat hepatocytes. These observations indicated that L-ascorbate also has potent cytoprotective role as it could reduce the NO production and normalize the cell proliferation and viability of hepatocytes. Therefore, the in vitro study suggested that ascorbic acid is helpful to ameliorate the arsenic-induced cytotoxicity and oxidative stress of rat hepatocytes.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0960327109357215

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