Acute Poisoning with Ibuprofen

Abstract

1 Seventy five cases of ibuprofen overdose were recorded during a two year survey.2 Details of the symptoms, treatment and the eventual outcome are known for 64% of the cases. The majority of the patients had no symptoms or only mild symptoms such as nausea or vomiting.3 In the three cases where more serious symptoms were reported, the role of ibuprofen was not certain.4 Laboratory analyses available for 13 cases demonstrated that plasma ibuprofen concentrations of up to 704 mg/l could be associated with no symptoms.5 The data suggest that ibuprofen is of low toxicity in acute overdose and that therapy used should be supportive only.