Poisoning with Veratrum-containing Sneezing Powders

Author:

Carlier P.1,Efthymiou M.-L.1,Garnier R.1,Hoffelt J.1,Fournier E.1

Affiliation:

1. Centre Anti-Poisons de Paris, 200 rue du Faubourg Saint-Denis, 75475 Paris

Abstract

1 Nine cases of accidental poisoning of children with sneezing powder are reported. Symptoms, besides sneezing, included gastrointestinal disturbances and syncope, whilst examination demonstrated bradycardia and hypotension. 2 The powder, as supplied, carried no information on its constituents but Veratrum alkaloids were identified on analysis. The signs and symptoms observed were compatible with poisoning from these compounds. 3 As a result of these observations, it was possible to trace the manufacturers and a change was made to a safer formulation. This example emphasises the value of toxicovigilance by Poison Control Centres.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology

Reference7 articles.

1. Benforado, J.M. (1968). The veratrum alkaloids in Physiological pharmacology , ed. W. S. Root and F. G. Hoffmann, vol.IV, part D, pp. 331-398. New York: Academic Press.

2. ON THE MECHANISM BY WHICH VERATRIDINE CAUSES A CALCIUM-INDEPENDENT RELEASE OF γ-AMINOBUTYRIC ACID FROM BRAIN SLICES

3. Krayer, O. (1958). In Veratrum alkaloids in pharmacology in medicine , 2nd ed, ed. V. A. Drill, pp. 515 -524, New York: McGraw Hill.

4. RAPID EFFECTS OF VERATRIDINE, TETRODOTOXIN, GRAMICIDIN D, VALINOMYCIN AND NaCN ON THE NA+, K+AND ATP CONTENTS OF SYNAPTOSOMES

5. Chemicals as tools in the study of excitable membranes.

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