Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes

Author:

Kim Yong-Dae1,Eom Sang-Yong1,Yan Wei Zhang 1,Kim Hyeongsu2,Park Jung-Duk3,Yu Seung-Do4,Lee Chul-Ho4,Arashidani Keiichi5,Kawamoto Toshihiro6,Kim Heon7

Affiliation:

1. Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea

2. Department of Preventive Medicine, School of Medicine, Konkuk University, Chungju, Chungbuk, South Korea

3. Department of Preventive Medicine, College of Medicine, Chungang University, Seoul, South Korea

4. Environmental Epidemiology Division, Environmental Health Research Department, National Institute of Environmental Research, Incheon, South Korea

5. Department of Environmental Management, School of Health Sciences and University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan

6. Environmental Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan

7. Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea,

Abstract

Urinary hippuric acid (HA) has been widely used as a biological marker of occupational exposure to toluene, although it is no longer valid for low levels of toluene exposure. Toluene exposure is known to induce oxidative DNA damage and the metabolism is affected by genetic polymorphisms of some metabolizing enzymes. Therefore, genetic polymorphisms of these metabolizing enzymes must be considered in the evaluation of oxidative stress caused by toluene exposure. We evaluated the relationship between urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and urinary HA in individuals without occupational exposure to toluene and characterized the possible roles of GSTM1, GSTT1, and aldehyde dehydrogenase 2 (ALDH2) genotypes in the relationships between these markers. In this study, we enrolled 92 healthy Koreans. Urinary HA and 8-OHdG levels were measured and the correlations between them were statistically tested according to the GSTM1, GSTT1, and ALDH2 genotypes. HA did not significantly correlate with urinary 8-OHdG in overall subjects. However, the correlation between them showed a statistical significance in individuals with GSTM1-null, GSTT1-null, and ALDH2 *2/*2 genotypes (r = 0.766, p < 0.01). This study shows that the relationship between urinary HA and 8-OHdG concentration is modified by genetic polymorphisms of some metabolizing enzymes such as GSTM1, GSTT1, and ALDH2.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

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