Frequency of flutamide induced hepatotoxicity in patients with prostate carcinoma

Author:

Çetin Mustafa1,Demirci Deniz2,Ünal Ali1,Altinbaş Mustafa1,Güven Muhammed3,Ünlühizarci Kürşat3

Affiliation:

1. Section of Hematology/Oncology, University of Erciyes, Kayseri, Turkey

2. Department of Urology, University of Erciyes, Kayseri, Turkey

3. Department of Medicine, University of Erciyes, Kayseri, Turkey

Abstract

To identify and describe the frequency and severity of hepatotoxicity in patients who received flutamide therapy for prostate cancer, 22 patients were treated with the combination of flutamide and goserilin or orchiectomy. After diagnosis and staging of prostate cancer, baseline results were obtained for a set of five liver function tests (LF Ts). Hepatotoxicity was assessed according to the WHO criteria. After initiation of flutamide therapy, LF Ts were performed at 4, 8 and 12 weeks and every 2 months thereafter. Severe hepatotoxicity appeared in two of 22 (9%) patients. Following the discontinuation of flutamide, one patient died due to acute liver failure. On the other patient an improvement of LF Ts occurred after cessation of flutamide. The observed severe hepatotoxicity in two of 22 (9%) patients occurred more frequent than is predicted in the literature. Patients treated with flutamide, having symptomatic or asymptomatic liver enzyme elevations, should be taken off therapy as soon as possible.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

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1. Flutamide-induced hepatotoxicity: A case report;Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale;2022-06-10

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3. Coenzyme Q 10 Abrogates Flutamide-induced Hepatotoxicity in Albino Rats;Journal of Medical Sciences and Health;2019-10-10

4. The effects of flutamide on cell-cell junctions in the testis, epididymis, and prostate;Reproductive Toxicology;2018-10

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