Affiliation:
1. Department of Clinical Pharmacology, Royal Postgraduate Medical School, Du Cane Road, London W12 OHS, UK
Abstract
1 By using a specific sensitive stable-isotope dilution gas chromatography-mass spectrometry (GC-MS) assay, hydrazine was detected in the plasma of eight healthy male volunteer subjects taking isoniazid (300 mg daily) for 2 weeks. 2 Accumulation of hydrazine occurred in slow-acetylator phenotypes. 3 Hydrazine was also detected in the plasma of eight out of 14 hypertensive patients treated chronically with hydralazine (200 mg daily). 4 However, the concentrations of hydrazine observed were much lower than in the isoniazid study and were close to the limit of detection. 5 As hydrazine is hepatotoxic, mutagenic and carcinogenic in animals, its presence in human plasma has important toxicological implications.
Subject
Health, Toxicology and Mutagenesis,Toxicology
Cited by
90 articles.
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