Acute Dapsone Poisoning: Clinical Features and Pharmacokinetic Studies-Reference-Cited by-同舟云学术

Acute Dapsone Poisoning: Clinical Features and Pharmacokinetic Studies

Published:1983-07 Issue:3 Volume:2 Page:507-510
ISSN:0144-5952
Container-title:Human Toxicology
language:en
Short-container-title:Human Toxicology

Author:

Woodhouse K.W.¹,Henderson D.B.¹,Charlton B.¹,Peaston R.T.²,Rawlins M.D.¹

Affiliation:

1. Wolfson Unit of Clinical Pharmacology, The University

2. Department of Clinical Biochemistry, Freeman Hospital, Newcastle upon Tyne

Abstract

1 A case of acute dapsone poisoning in a 57 year old man is reported. Peak plasma dapsone concentrations of 18.8 mg/l were observed 20 hours after ingestion, and methaemoglobin concentrations fell in parallel with dapsone. 2 Plasma dapsone concentrations declined mono-exponentially with time, and the half-life (29.7 hours) was similar to that described in subjects receiving conventional doses. Moreover, the ratio of monoacetyl-dapsone (MADDS) to dapsone remained constant as plasma concentrations fell. These observations suggest that N-acetylation of dapsone was not saturated even at the toxic concentrations observed.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/096032718300200306

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