Affiliation:
1. Sections of Cardiology & Nephrology, Department of Internal Medicine, Taiwan Veterans General Hospital & National Yang-Ming Medical College, Taipei, Taiwan, Republic of China
Abstract
1 Plasma propranolol levels were measured in a woman who took 3120 mg of propranolol in a suicide attempt. 2 Highest plasma level, measured at the 12th hour, was 1475 ng/ml. Elimination half life was prolonged to 13.8 h. 3 She suffered from coma and profound hypotension, then died on the 20th day. 4 By estimating brain propranolol concentration from the plasma level, and reviewing the clinical pictures of previously reported cases, we propose that central nervous suppression by propranolol, with membrane stabilizing effect as its pharmacological basis, may cause life threatening abnormalities in patients with massive overdose of propranolol.
Subject
Health, Toxicology and Mutagenesis,Toxicology
Reference24 articles.
1. Bowman, W.C. & Rand, M.J. (1980). Textbook of Pharmacology, 2nd edn, pp.8:5; 16:29. Oxford: Blackwell.
2. British National Formulary, (1981). Number 2, p.64. London: British Medical Association and the Pharmaceutical Society.
3. Plasma Propranolol Levels in the Quantitative Assessment of -adrenergic Blockade in Man
4. The clinical importance of cardioselectivity and lipophilicity in beta blockers
Cited by
21 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献