Affiliation:
1. Department of Forensic Medicine, University of Helsinki, Kytösuontie 11, SF-00300 Helsinki, Finland
Abstract
Fatal massive peripheral zonal hepatic necrosis developed in a 47-year-old man who accidentally ingested a solution of methyl ethyl ketone peroxide (MEKP) in dimethyl phtalate. Such solutions contain about 10% active oxygen. The clinical course was characterized by temporary cardiac arrest, abdominal burns, severe metabolic acidosis, rapid hepatic failure, rhabdomyolysis and respiratory insufficiency. A fatal outcome resulted 4 d afterwards from hepatic coma associated with blood coagulation disorders. Microscopical examination revealed massive periportal hepatic necrosis accompanied by atypical pseudoductular proliferation. The proliferating cells were probably of bile duct origin and exhibited atypia and mitoses. The pathogenetic mechanism may involve lipid peroxidation caused by free oxygen radicals derived from MEKP.
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Reference7 articles.
1. Suicide by Ingestion of Methyl Ethyl Ketone Peroxide
2. Toxicity Studies of Certain Organic Peroxides and Hydroperoxides
3. Ishak KG The liver. In Pathology of drug-induced and toxic diseases , ed. R.H. Riddell pp. 457-513. New York: Churchill Livingstone, 1982 .
4. Bus JS & Gibson JE Lipid peroxidation and its role in toxicology. In Reviews in biochemical toxicology 1, eds E. Hodgson, JR Bend & RM Philpot pp. 125-49. New York: Elsevier North Holland, 1979.
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献