Histopathological effects of Illudin S, a toxic substance of poisonous mushroom, in rat

Abstract

1 Rats were dosed orally with illudin S, a toxic substance derived from the poisonous mushroom Lampteromyces japonicus. The digestive tract showed severe damage, whereas the liver, kidney and lung did not show any significant changes. 2 The effects observed became more pronounced with increasing illudin S dose (5, 10 or 20 mg kg -1 body weight). 3 Severe inflammation and oedema were observed in the stomach and moderate changes in the proximal part of the small intestine. 4 Histopathological examination revealed haemorrha gic erosions and marked inflammatory oedema in the gastric mucosa.