Affiliation:
1. Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne, Newcastle NE1 7RU, UK
Abstract
Adverse hepatic reactions to nitrofurantoin therapy are well reported and range from acute cholestatic or hepatitic injury to chronic active hepatitis [R. G. Penn & J. P. Griffin (1982) Br. Med. J., 284, 1440-1442]. Neurological side-effects, predominantly sensorimotor peripheral poly-neuropathy, have also been documented [R. G. Penn & J. P. Griffin (1982)]. We report the first case of combined neurological and hepatic reaction to nitrofurantoin; this occurred during repeated treatment with the drug.
Subject
Health, Toxicology and Mutagenesis,Toxicology
Cited by
7 articles.
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1. Nitrofurantoin;Meyler's Side Effects of Drugs;2016
2. Nitrofurantoin-Induced Hepatotoxicity: A Rare Yet Serious Complication;Southern Medical Journal;2014-02
3. Autoimmune Hepatitis Induced by Nitrofurantoin. The Importance of the Autoantibodies for an Early Diagnosis of Immune Disease;Clinics and Practice;2012-10-17
4. ANTIBACTERIAL DRUGS;Meyler's Side Effects of Antimicrobial Drugs;2010
5. Nitrofurantoin;Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions;2006