Affiliation:
1. PO Bag 4000, Alberta Environmental Centre, Vegreville, Alberta, Canada T9C 1 T4
Abstract
1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters. 2 Nine of these parameters were associated with growth and developmental changes in males between 38 - 78 days and females 49 - 89 days of age. 3 Weight gain in both sexes followed patterns consistent with other studies using this strain, but interexperi mental variation was as much as ± 22%. 4 Rectal temperatures of females averaged 37.28°C, being statistically greater (P < 0.05) than the average male at 36.99°C. 5 The data provide reference values for use in toxicolo gical and other investigations.
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Reference15 articles.
1. Ringler DH, Dabich L. Hematology and clinical chemistry. In: Baker JH, Lindsey JR and Weisbroth SH eds. The Laboratory Rat vol 1. Academic Press, New York, 1979, pp. 105-21.
2. Using Historical Controls in the Analysis of Developmental Toxicity Data
3. The use of historical control information in modelling dose response relationships in carcinogenesis
4. Gad FC, Weil CS Statistics for toxicologists. In: Wallace Hayes A, ed. Principles and Methods of Toxicology. Raven Press, NY, 1989 , pp. 435-83.
Cited by
86 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献