Selective Inhibition of Gastrointestinal β-Glucuronidase by Polyvinylbenzyl D-glucaro(1,4)lactonate: Attachment of D-Glucaro(1,4)lactone to Polyvinylbenzyl Chloride-Reference-Cited by-同舟云学术

Selective Inhibition of Gastrointestinal β-Glucuronidase by Polyvinylbenzyl D-glucaro(1,4)lactonate: Attachment of D-Glucaro(1,4)lactone to Polyvinylbenzyl Chloride

Published:1993-03 Issue:2 Volume:12 Page:181-184
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Sacco C.¹,McEwen W.E.²,Calabrese E.J.¹

Affiliation:

1. Environmental Health Sciences Program, School of Public Health

2. Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA

Abstract

D-Glucaro(1,4)lactone, a potent β-glucuronidase inhibitor was attached via the carboxylic acid moiety to polyvinylbenzyl chloride (PVBC) using a bimolecular nucleophilic displacement reaction, First, the caesium salt of D-glucaro(1,4)lactone was prepared by titrating the carboxylic acid to neutrality with aqueous caesium bicarbonate. The polyvinylbenzyl D-glucaro(1,4)lactonate was obtained in maximum yields of between 50 and 60% when caesium D-glucaro(1,4)lactonate was incubated with PVBC in DMF at 50°C for 7 d in the presence of a catalyst, caesium iodide.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/096032719301200216

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4. Evidence that d-glucaro-1,4-lactone shortens the pharmacological action of drugs being disposed via the bile as glucuronides

5. Chemical modification of polymers. II. Reaction of poly(vinylbenzyl chloride) and phenols

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