Clinical and Sub-clinical Lead Poisoning: A Laboratory Perspective

Abstract

1 The background, scope and limitations of laboratory methods for the diagnosis of inorganic dead poisoning are outlined in the context of the work of a specialist clinical laboratory for trace element analysis. 2 Data for blood lead, haemoglobin and erythrocyte zinc protoporphyrin concentrations are presented in cases of clinical and sub-clinical poisoning due to accidental or occupational exposure. 3 Data from population surveys of children and adults subject to either environmental or occupational exposure are also shown. 4 In general, analysis for lead in an appropriate specimen of blood offers the single most useful index of exposure. 5 The importance of good accuracy control in such measurements is emphasized.