Organochlorine compounds in human brain-Reference-Cited by-同舟云学术

Organochlorine compounds in human brain

Published:1996-03 Issue:3 Volume:15 Page:262-264
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Corrigan FM¹,French M.²,Murray L.³

Affiliation:

1. Argyll and Bute Hospital, Lochgilphead, Argyll, PA30 8HH, Scotland

2. Institute of Terrestrial Ecology, Abbots Ripton, Huntingdon, Cambridgeshire

3. Consultant Pathologist, Vale of Leven District General Hospital, Alexandria, Dumbartonshire

Abstract

Having observed polychlorinated biphenyls (PCBs) in brain tissue obtained post mortem from two men we have carried out a study of organochlorine compounds in frontal cortex from patients with Parkinson's disease (PD) and from controls. No PCBs were found in any of those samples. There was no difference in the concentra tion of the DDT metabolite pp'-DDE in the PD brain samples. Dieldrin (HEOD) was significantly decreased in PD brain when analysed by lipid weight. While these findings would not support the hypothesis that PCBs may contribute to the development of Parkinson's disease in humans it remains possible that they may cause damage to the basal ganglia before being displaced from brain tissue.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/096032719601500314

Reference11 articles.

1. Organochlorine pesticide residues in human fat in the United Kingdom 1976-7.

2. Exposure to low doses of the environmental chemical dieldrin causes behavioral deficits in animals prevented from coping with stress

3. Neurasthenic fatigue, chemical sensitivity and GABAa receptor toxins

4. Neurobehavioral Dysfunction in Firemen Exposed to Polychlorinated Biphenyls (PCBs): Possible Improvement after Detoxification

5. Decreases in dopamine concentrations in adult, non-human primate brain persist following removal from polychlorinated biphenyls

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