Serum procarboxypeptidase A and carboxypeptidase A levels in pancreatıc disease-Reference-Cited by-同舟云学术

Serum procarboxypeptidase A and carboxypeptidase A levels in pancreatıc disease

Published:2011-04-18 Issue:5 Volume:31 Page:447-451
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Kemik Ozgur¹,Kemik Ahu Sarbay²,Sumer Aziz¹,Beğenik Hüseyin³,Dülger Ahmet Cumhur⁴,Purisa Sevim⁵,Tuzun Sefa⁶

Affiliation:

1. Department of General Surgery, Medical Faculty, University of Yüzüncü Yıl University,Van, Turkey

2. Department of Biochemistry, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

3. Department of Internal Medicine, Medical Faculty, University of Yüzüncü Yıl University, Van, Turkey

4. Department of Gastroenterology, Medical Faculty, University of Yüzüncü Yıl University, Van, Turkey

5. Department of Biostatistics, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

6. Department of 2nd General Surgery, Haseki Training Hospital, Istanbul, Turkey

Abstract

Background and objectives: To determine the serum levels of procarboxypeptidase A (pro-CPA) and carboxypeptidase A (CPA) in patients with acute and chronic pancreatitis and pancreatic cancer. Materials and methods: Serum samples obtained from 96 patients with acute pancreatitis, 101 patients with chronic pancreatitis, 98 patients with pancreatic cancer and 96 control groups were assayed for biochemical parameters and serum pro-CPA and CPA. Results: Serum pro-CPA and CPA levels were significantly higher in acute and in chronic pancreatic cancer patients compared to control group ( p < 0.001). Pancreatic cancer patients had significantly higher serum pro-CPA and CPA levels when compared with acute and chronic pancreatitis cases ( p < 0.001). Conclusion: These data prove for increased pro-CPA and CPA levels as a biomarker for the diagnosis of pancreatitis and pancreatic cancer.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0960327111405864

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