Phenyl Valerate and Choline Ester Hydrolases in the Platelets of Human, Hen, Rat and Mouse

Abstract

1 The levels of phenyl valerate and choline ester hydrolases in the platelets of human and certain laboratory animals have been determined for comparison. 2 The activities of total phenyl valerate hydrolase (PVase), paraoxon insensitive phenyl valerate hydrolase (PI-PVase), paraoxon and mipafox resistant esterase (PMRE) and propionylcholinesterase (PChE) were maximal in hen followed by mouse, rat and human. 3 Neurotoxicesterase (NTE) and acetylcholinesterase (AChE) activities were concentrated in the platelets of hens followed by humans, rats and mice in order. 4 Maximum concentration of butyrylcholinesterase (BChE) was found in the platelets of hens followed by mice, humans and rats. 5 It is concluded that the normal levels of enzyme activities in the platelets of humans and various species of animals may help to evaluate the exposure risk to neurotoxic organophosphorous compounds.