Carbamazepine and Carbamazepine-10,11-epoxide Pharmacokinetics in an Overdose Patient-Reference-Cited by-同舟云学术

Carbamazepine and Carbamazepine-10,11-epoxide Pharmacokinetics in an Overdose Patient

Published:1987-05 Issue:3 Volume:6 Page:241-244
ISSN:0144-5952
Container-title:Human Toxicology
language:en
Short-container-title:Human Toxicology

Author:

Patsalos P.N.¹,Krishna S.²,Elyas A.A.³,Lascelles P.T.³

Affiliation:

1. Department of Chemical Pathology, The National Hospital, Queen Square, London WC1N 3BG, Chalfont Centre for Epilepsy, Chalfont St Peter, Gerrards Cross, Buckinghamshire SL9 ORJ

2. Wexham Park Hospital, Slough SL2 4HL, UK

3. Department of Chemical Pathology, The National Hospital, Queen Square, London WC1N 3BG

Abstract

1 A case report on a 13-year-old girl with idiopathic grand mal epilepsy who ingested 34 g carbamazepine (CBZ) and 80 mg clonazepam is presented. 2 The patient survived but suffered severe temporary neurological toxicity characteristic of CBZ. 3 CBZ was 79.6 ± 2.8% bound to serum protein and carbamazepine-10,11-epoxide (CBZ-E) binding was essentially concentration dependent. 4 CBZ and CBZ-E elimination half-lives were 26 and 16.5 h respectively. An inhibitory metabolic interaction with the co-ingested clonazepam is suggested.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/096032718700600312

Reference19 articles.

1. Advanced heart block aggravated by carbamazepine.

2. Fatal carbamazepine hepatitis

3. An Unusual Case of Carbamazepine Poisoning with a Near-Fatal Relapse after Two Days

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