Short Review: Benzene's toxicity: a consolidated short review of human and animal studies-Reference-Cited by-同舟云学术

Short Review: Benzene's toxicity: a consolidated short review of human and animal studies

Published:2007-09 Issue:9 Volume:26 Page:677-685
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Ahmad Khan Haseeb¹

Affiliation:

1. Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia,

Abstract

A large population of humans is exposed to benzene from various occupational and environmental sources. Benzene is an established human and animal carcinogen. Exposure to benzene has been associated with leukaemia in humans and several types of malignancies in animals. The exact mechanism of benzene-induced toxicity is poorly understood. It is believed that benzene exerts its adverse effects by metabolic activation to toxic metabolites. Certain benzene metabolites are genotoxic and mutagenic. This consolidated short-review is composed of human and animal studies to summarize the adverse effects of benzene with special reference to molecular mechanisms involved in benzene-induced toxicity. Human & Experimental Toxicology (2007) 26, 677— 685

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0960327107083974

Reference121 articles.

1. DNA damage in lymphocytes of benzene exposed workers correlates with trans,trans-muconic acids and breath benzene levels

2. Aplastic anemia in a young coke plant worker

3. Risk of low red or white blood cell count related to estimated benzene exposure in a rubberworker cohort (1940-1975)

4. Comparison of exposure assessment methods in occupational exposure to benzene in gasoline filling-station attendants

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