Kaempferol, a mutagenic flavonol from Helichrysum simillimum-Reference-Cited by-同舟云学术

Kaempferol, a mutagenic flavonol from Helichrysum simillimum

Published:2008-11 Issue:11 Volume:27 Page:845-849
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Elgorashi EE¹,van Heerden FR²,van Staden J¹

Affiliation:

1. Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa

2. School of Chemistry, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa

Abstract

Helichrysum simillimum is native to South Africa. It is used for the treatment of coughs, colds, fever, infections, headache, and menstrual pain. Extracts of this species showed mutagenic effects in the Salmonella/microsome assay. The aim of this study was to isolate and determine the mutagenic constituents of H. simillimum. Bioassay-guided fractionation of 90% aqueous methanol extracts, using Salmonella typhimurium TA98, led to the isolation of the flavonol kaempferol.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0960327108099532

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