The Rarity of Liver Toxicity in Patients Treated with Coumarin (1, 2-Benzopyrone)-Reference-Cited by-同舟云学术

The Rarity of Liver Toxicity in Patients Treated with Coumarin (1, 2-Benzopyrone)

Published:1989-11 Issue:6 Volume:8 Page:501-506
ISSN:0144-5952
Container-title:Human Toxicology
language:en
Short-container-title:Human Toxicology

Author:

Cox D.¹,O'Kennedy R.¹,Thornes R.D.²

Affiliation:

1. School of Biological Sciences, National Institute for Higher Education, Glasnevin, Dublin 9

2. Beaumont Hospital, Dublin 9, Ireland

Abstract

1 Two thousand, one hundred and seventy-three patients with cancer or chronic infections were treated with coumarin in a clinical trial. 2 0.37% of these patients developed elevated liver enzyme levels during therapy with coumarin. 3 This hepatitis was probably a form of idiosyncratic hepatotoxicity and may have been immune in origin.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/096032718900800612

Reference26 articles.

1. 3 The Metabolism and Biological Actions of Coumarins

2. Two-year toxicity study on coumarin in the baboon

3. Metabolism of Coumarin in Man

4. Analysis of coumarin and its urinary metabolites by high-performance liquid chromatography

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