Low-dose diethyldithiocarbamate attenuates the hepatotoxicity of 1,3-Dichloro-2-propanol and selectively inhibits CYP2E1 activity in the rat-Reference-Cited by-同舟云学术

Low-dose diethyldithiocarbamate attenuates the hepatotoxicity of 1,3-Dichloro-2-propanol and selectively inhibits CYP2E1 activity in the rat

Published:1997-05 Issue:5 Volume:16 Page:262-266
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Stott Ian¹,Murthy Anupama²,Robinson Alex²,Thomas Norman W¹,Fry Jeffrey R²

Affiliation:

1. Department of Human Anatomy and Cell Biology, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK

2. Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre

Abstract

The effect of low doses of diethyldithiocarbamate (DEDC) on hepatic cytochrome P450-dependent enzyme activity and 1,3-dichloro-2-propanol (DCP) hepatotoxicity in the rat have been investigated. DEDC at a dose of 5 mg/kg selectively inhibited enzyme markers for CYP2E1 activity, and provided substantial protection against DCP hepato toxicity. At a higher dose (25 mg/kg), DEDC also inhibited an enzyme marker for CYP1A2 activity and provided complete protection against DCP hepatotoxicity. It is concluded: (a) that DEDC at a dose of 5 mg/kg is a selective CYP2E1 inhibitor in the rat in vivo; and (b) that DCP hepatotoxicity is mediated principally by CYP2E1, with a possible contribution from CYP1A2.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/096032719701600505

Reference22 articles.

1. Submassive hepatic necrosis induced by dichloropropanol

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