Transplacental Carcinogenesis with Radioactive Phosphorus

Author:

Berry C.L.1,Amerigo J.2,Nickols C.1,Swettenham K.V.1

Affiliation:

1. Department of Morbid Anatomy, The London Hospital, London, E1 1BB

2. Department of Morbid Anatomy, The London Hospital, London, E1 1BB, Depto de Anatomia Patologica, Hospital Universitario, Sevilla, Spain

Abstract

1 An attempt was made to produce a model of osteogenic sarcoma using 32P transplacentally. 2 Fetal tissues appeared to be resistant to irradiation as no tumour was induced at an increased frequency in treated animals. 3 Tumours that normally occur in our strain (Sprague-Dawley rats) showed a clear tendancy to occur earlier in post-natal life in treated animals compared with controls.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology

Reference30 articles.

1. Alexandrov, V.A. (1973). Embryotoxic and teratologic effects of chemical carcinogenesis. In: L. Tomatis & U. Mohr (eds), Transplacental Carcinogenesis, IARC Scientific Publications No. 4, pp. 112-126. Lyon, France: International Agency for Research on Cancer.

2. The ultrastructure of skeletal haemangiosarcomas induced in mice by strontium-90

3. Histological and Dosimetric Considerations of Bone Tumour Production with Radioactive Phosphorus

4. Aetiological factors in childhood neoplasia.

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