Effect of Occupational Lead Exposure on Serum 1,25-dihydroxyvitamin D Levels-Reference-Cited by-同舟云学术

Effect of Occupational Lead Exposure on Serum 1,25-dihydroxyvitamin D Levels

Published:1990-01 Issue:1 Volume:9 Page:29-34
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Mason H.J.¹,Somervaille L.J.²,Wright A.L.¹,Chettle D.R.²,Scott M.C.²

Affiliation:

1. Occupational Medicine and Hygiene Laboratories, Health and Safety Executive, 403-405, Edgware Road, London, NW2 6LN

2. School of Physics and Space Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

Abstract

The effects of lead exposure on serum 1,25-dihydroxyvitamin D levels and calcium homeostasis have been studied in 63 males occupationally exposed to the metal in the UK. The exposure indices used were blood lead, reflecting short-term exposure, and an in vivo X-ray fluorescence measurement of tibia lead which reflects cumulative lead exposure. Serum 1,25-dihydroxyvitamin D levels were higher than those in a referent population, who were non-occupationally exposed to lead, and were correlated with both blood lead and tibia lead. Multiple regression analysis suggested that blood lead was the variable responsible for the increase in serum 1,25-dihydroxyvitamin D. There were no other abnormalities in calcium metabolism associated with the degree of lead exposure.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/096032719000900107

Reference32 articles.

1. Chronic lead nephropathy

2. Nephropathy in Chronic Lead Poisoning

3. Occupational lead nephropathy

4. Blood lead concentration, blood pressure, and renal function.

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