Human Metabolism of Arsenobetaine Ingested with Fish-Reference-Cited by-同舟云学术

Human Metabolism of Arsenobetaine Ingested with Fish

Published:1990-01 Issue:1 Volume:9 Page:41-46
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Brown R.M.¹,Newton D.¹,Pickford C.J.¹,Sherlock J.C.²

Affiliation:

1. Environmental and Medical Sciences Division, Harwell Laboratory, Didcot, Oxon OX11 ORA

2. Food Science Division, Ministry of Agriculture, Fisheries & Food, Smith Square, London SW1P 3HX, UK

Abstract

1 Six volunteers ingested 74As-labelled arsenobetaine with a fish meal. The retention and distribution of the tracer were studied by body radioactivity measurements. 2 The tracer became rapidly dispersed in soft tissues, with no major concentration in any localized organ or region. 3 In all subjects < 1% of the ingested activity remained in the body after 24 days. 4 Any losses from the skin were minor in relation to those by other routes of excretion.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/096032719000900109

Reference18 articles.

1. Cannon JR, Edmonds JS, Francesconi KA & Langsford JB Arsenic in marine fauna. In: Management and Control of Heavy Metals in the Environment, pp. 283-286. Edinburgh: CEP Consultants, 1979.

2. Occurrence of arsenic in plaice (Pleuronectes platessa), nature of organo-arsenic compound present and its excretion by man.

3. Excretion of a single oral dose of fish-arsenic in man

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