Protective effect of alpha-pinene against isoproterenol-induced myocardial infarction through NF-κB signaling pathway

Author:

Zhang B1,Wang H2,Yang Z3,Cao M4,Wang K5,Wang G6,Zhao Y7ORCID

Affiliation:

1. Department of Health Care Center, Beijing Friendship Hospital Medical, Capital Medical University, Beijing, China

2. Department of Pharmacy, The First Affiliated Hospital of Nanhua University, Hengyang City, Hunan Province, China

3. Department of ICU, The First People’s Hospital of Huaihua, Huaihua City, Hunan Province, China

4. Department of Cardiovascular, The People’s Hospital of Tianjin, Tianjin City, China

5. Department of Endocrinology, Tianyou Hospital Affiliated to Tongji University, Shanghai, China

6. Department of Endocrinology, The Putuo People’s Hospital Affiliated to Tongji University, Shanghai, China

7. Department of Cardiovascular Biology, Changsha Central Hospital, Changsha City, Hunan Province, China

Abstract

Monoterpenes present in the essential oils exhibit anti-inflammatory properties. In this study, we investigated the preventive effect of alpha-pinene (AP), a monoterpene, against isoproterenol (ISO)-induced myocardial infarction and inflammation in Wistar rats. Male Wistar rats were pretreated with AP (50 mg/kg body weight (bw)) administration for 21 days and ISO (85 mg/kg bw) was administered subcutaneously for last two consecutive days (20th day and 21st day). We noticed that there was an increased activity of cardiac marker enzymes in ISO-treated rats. We also observed that elevated levels of lipid peroxidative indices decreased activities of antioxidant status in plasma, erythrocyte, and heart tissue in ISO-induced rats. Furthermore, ISO-treated rats showed an increase in the levels of inflammatory mediators like tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the serum. Besides, we confirmed the upregulated expression of TNF-α, IL-6, and nuclear factor kappa-light-chain-enhancer of activated B cells in ISO-induced rat heart tissue. Conversely, we found that AP pretreatment significantly decreased levels of cardiac markers like serum cardiac troponin T and cardiac troponin I, lipid peroxidative markers, and restored antioxidants status in ISO-treated rats. Besides, AP administration attenuated ISO-induced inflammatory marker expression. The present findings demonstrated that AP significantly protects the myocardium and exerts cardioprotective and anti-inflammatory effects in experimental rats.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

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