Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary

Author:

Khan A1ORCID,Feulefack J1,Sergi CM123ORCID

Affiliation:

1. Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Edmonton, AB, Canada

2. Department of Pediatrics, Stollery Children’s Hospital, University of Alberta Hospital, Edmonton, AB, Canada

3. Division of Anatomic Pathology, University of Ottawa, Ottawa, ON, Canada

Abstract

Background There are hereditary types of nephroblastoma or Wilms’ tumor associated with exposure of the germ cells of either parent to harmful environmental factors. Some studies have examined the exposure of compounds used pesticides and herbicides as a risk factor for Wilms’ tumor. Methods A systematic review and meta-analysis were carried out on case-control studies to establish the potential link between exposure to these organic molecules and Wilms’ tumor occurrence in children rigorously. We examined the monographs on some organo-phosphate insecticides and herbicides issued by the International Association for the Research on Cancer (IARC) under the auspices of the World Health Organization (WHO). PUBMED, SCOPUS, and Google Scholar studies (1960–2021) were identified and systematically reviewed following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Subgroup analyses were conducted after stratification for occupational versus residential exposure and before birth (prenatal) vs. after birth (postnatal) exposure. In addition, we revised the monographs on chemical compounds issued recently by the IARC/WHO. Results Our findings seem to consolidate that parental pesticide exposure during the preconception or pregnancy period is correlated with an increased occurrence risk for Wilms’ tumor. We confirm the validity of the WHO essays on certain organophosphate herbicides and insecticides, which support these compounds, may be highly relevant in future cancer prevention policies. Conclusion Parental exposure to pesticides, particularly in household settings, is poorly emphasized in our society. There is a strong association between these organophosphate compounds and pediatric cancer. Public health agencies may need to take stronger action than in the past.

Funder

Women and Children’s Health Research Institute

Hubei University of Technology

Fonds zur Förderung der wissenschaftlichen Forschung

Canadian Foundation for Women’s Health

Cancer Research Society

Canadian Institutes of Health Research

Saudi Cultural Bureau, Ottawa, Canada

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

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