Determination of Serum Diclofenac by High-performance Liquid Chromatography by Electromechanical Detection-Reference-Cited by-同舟云学术

Determination of Serum Diclofenac by High-performance Liquid Chromatography by Electromechanical Detection

Published:1985-05 Issue:3 Volume:4 Page:317-322
ISSN:0144-5952
Container-title:Human Toxicology
language:en
Short-container-title:Human Toxicology

Author:

Plavsic F.¹,Čulig J.¹

Affiliation:

1. Section of Clinical Pharmacology, Department of Medicine, Clinical Hospital Centre Zagreb, Medical Faculty University of Zagreb, Yugoslavia

Abstract

Diclofenac was isolated from plasma by double extraction with organic solvent. Chromatography was performed on Lichrosorb NH2 column with acetonitrile and perchloric acid (0.0025 mol/l; 35:65, v/v) as the mobile phase (flow rate 0.9 ml/min). The electrochemical detector was operated at +900 mV and sensitivity of 5-10 nA. The sensitivity of the method was 10 μg/1 and the coefficients of variation below 10% in the entire range of the concentration in a dose interval.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/096032718500400313

Reference6 articles.

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