Affiliation:
1. Pre-Clinical Safety Consultants Est., 7 Earning Street, Godmanchester, Huntingdon, Cambs. PE18 8JD, UK
2. University of Utah, School of Medicine, 50 North Medical Drive, Salt Lake City, Utah 84132, USA
Abstract
This paper describes control of normal Leydig cell func tion and testosterone production. The macroscopic and histopathological appearances of spontaneous Leydig cell hyperplasias and tumors (LCT) in the rat are reviewed together with their incidence and hormonal status. Drugs which induce LCTs in chronic studies are discussed and include busereline, carbamazepine, cimetidine, finas teride, flutamide, gemfibrozil, histrelin, hydralazine, indomethacin, isradipine, lactitol, leuprolide, metronida zole, mesulergine, nafarelin, norprolac and vidarabine. The known mechanisms of LCT induction in the rat are reviewed together with other possible etiological factors. The incidence, clinical picture and etiological factors of LCTs in man are also surveyed. Hormone production in Leydig cells and LCTs in rats and man are compared. Differences between the two species are considered, par ticularly with regard to Leydig cell control mechanisms. The paper concludes that drug-induced LCTs in rats are most probably not predictive for man and their occurrence has little relevance in human safety assessment.
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Reference98 articles.
1. Boorman GA, Chapin CE, Mitsumori K. Testis and epidiymis In: Pathology of the Fischer Rat. Reference and Atlas, Boorman GA, Eustis SL, Elwell MR, Montgomery CA (eds), London: Academic Press , pp. 405-417, 1990.
2. Prentice DE, Siegel RA, Donatsch P., Qureshi S., Ettlin RA Mesulergine induced Leydig cell tumours, a syndrome involving the pituitary-testicular axis of the rat Archives of Toxicology , Supplement 15, Proceedings of the 1991 Eurotox Congress Meeting held in Masstricht, September 1-4, 1991. Bolt HM, de Wolff FA, Henderson PTh (eds), Springer-Verlag, pp 197-203.
3. Nielsen SW, Kennedy PC Tumors of the genital systems In: Tumours in Domestic Animals 3rd Edition, Moulton JE (ed), University of California Press, pp 483-485,1990.
4. Morphometric analysis of Leydig cells in the normal rat testis.
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