Transient electroencephalographic suppression with initiation of cardiopulmonary bypass in pigs: blood versus nonblood priming

Author:

Conroy Brendan P1,Lin Cheng Y1,Jenkins Larry W1,DeWitt Douglas S1,Johnston William E2

Affiliation:

1. Division of Cardiothoracic Anesthesiology and the Charles R Allen Research Laboratories, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas

2. Division of Cardiothoracic Anesthesiology and the Charles R Allen Research Laboratories, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas,

Abstract

Electroencephalographic (EEG) changes have been reported with cardiopulmonary bypass (CPB). We tested whether the type of priming solution (blood versus nonblood) affected the EEG. Twenty-six anesthetized pigs (29.5 ± 1.6 kg) were cannulated for CPB primed with 1 liter plasmalyte and 500 ml 6% hetastarch (nonblood prime). EEG signals were recorded during the initiation of normothermic CPB. Three minutes later, animals were weaned from CPB and allowed to stabilize. CPB was reinstituted using the animals’ hemodiluted blood as prime. We found that with nonblood prime, abrupt and marked EEG suppression lasting 12.6 ± 0.7 s was found in all animals, followed by gradual resumption of baseline EEG activity. In contrast, CPB with blood prime caused no detectable EEG changes. We conclude that severe reductions in EEG activity occur after initiating CPB with nonblood prime; these reductions are not seen when using blood prime. The cause of EEG suppression is unknown, but may represent transient impairment of oxygen delivery to the brain caused by nonblood perfusion.

Publisher

SAGE Publications

Subject

Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Safety Research,Radiology, Nuclear Medicine and imaging,General Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Advances in Bloodless Open-Heart Surgery;Low Invasive Pediatric Cardiac Surgery;2022-12-07

2. The Effect of Retrograde Autologous Priming of the Cardiopulmonary Bypass Circuit on Cerebral Oxygenation;Journal of Cardiothoracic and Vascular Anesthesia;2011-12

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