Comparison of red blood cell transfusions and hemostatic transfusions and their relation to thromboses in pediatric patients receiving extracorporeal membrane oxygenation therapy

Author:

Martinez Michael J1ORCID,Romero Tahmineh2,Federman Myke D3

Affiliation:

1. Department of Pediatrics, Division of Cardiology, Hassenfeld Children’s Hospital at NYU, New York, NY, USA

2. Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, Los Angeles, CA, USA

3. Department of Pediatrics, Division of Critical Care Medicine, Mattel Children’s Hospital at UCLA, Los Angeles, CA, USA

Abstract

Objective To evaluate the association of RBC transfusions with thrombosis in pediatric patients on extracorporeal membrane oxygenation (ECMO) and compare this with the transfusion of other blood products and their association with thrombosis. Methods This was a secondary analysis of the Bleeding and Thrombosis during ECMO (BATE) study, which was a multicenter prospective observational study involving patients less than 19 years of age treated with ECMO. Results 514 patients were analyzed, of which 282 (55%) were neonates (≤31 days) and 302 (58.7%) were male. When analyzing the entire cohort independently of other blood products, each 10 mL/kg of packed red blood cells (PRBCs) was associated with a 1.0% increase in the average number of thromboses (1.010; 1.008,1.013; p < .001). In neonates, each 10 mL/kg of PRBC was associated with a 0.9% increase in the average number of thromboses (1.009; 1.003,1.013; p < .001). In pediatric patients, each 10 mL/kg of PRBC was associated with a 1.2% increase in the average number of thromboses (1.012; 1.008,1.012; p < .001). The percent increase in the average number of thromboses was similar between PRBCs, platelets, and FFP, but increased significantly with cryoprecipitate. Conclusions RBC transfusions and hemostatic transfusions are likely associated with thromboses in pediatric patients on ECMO.

Publisher

SAGE Publications

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