Modified ultrafiltration in paediatric cardiopulmonary bypass

Author:

Wang Wei1,Huang Hui Ming1,De Ming Zhu 1,Chen Hong1,Su Zhao Kang1,Ding Wei Xiang1

Affiliation:

1. Department of Paediatric Cardiothoracic Surgery, Xinhua Hospital, Shanghai Second Medical University, Shanghai

Abstract

Cardiopulmonary bypass (CPB), a nonphysiological procedure, is associated with haemodilution and the inflammatory response, causing the accumulation of body water and organ dysfunction. The purpose of this study was to evaluate the efficacy of modified ultrafiltration. Forty paediatric patients undergoing cardiac operations were randomized into a control group and a modified ultrafiltration group. Blood cells, protein and cytokine concentrations were recorded for 24 h postoperatively. As the fluid was removed at 50 ml/min, both blood cells and protein were concentrated by modified ultrafiltration ( p < 0.001). The tumour necrosis factor (TNF)-α concentration was increased and interleukin-8 (IL-8) and endothelin (ET) concentrations were unaltered after ultrafiltration. After correction for albumin, TNF-α concentration changed little, and IL-8 and ET concentrations (36.75 ± 12.35, 42.89 ± 15.54) were decreased significantly (21.47 ± 13.87, 26.06 ± 12.54) after ultrafiltration. Modified ultrafiltration is an effective method for removing excess tissue fluid and concentrating blood after CPB. This technique can also filter out some cytokines.

Publisher

SAGE Publications

Subject

Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Safety Research,Radiology, Nuclear Medicine and imaging,General Medicine

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