Dual immunoadsorption for ABO-incompatible heart transplantation in a 35 kg child

Author:

Crook Richard1ORCID,Cohen Marc2,Mimic Branko3,Fenton Matthew45,Issitt Richard15ORCID

Affiliation:

1. Department of Perfusion, Great Ormond Street Hospital for Children, London, UK

2. Department of Anaesthetics, Great Ormond Street Hospital for Children, London, UK

3. Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Children, London, UK

4. Department of Cardiothoracic Transplantation, Great Ormond Street Hospital for Children, London, UK

5. Centre for Heart Failure, Transplantation and Extracorporeal Support, Research Department of Children’s Cardiovascular Disease, UCL Institute of Cardiovascular Science, London, UK

Abstract

Intraoperative anti-A/B immunoadsorption (ABO-IA) was recently introduced for ABO-incompatible (ABOi) heart transplantation. Here we report the first case of a patient transplanted with ABO-IA, that was of an age and weight that required two ABO-IA columns run in parallel, to enable the reduction in antibody titres to a sufficiently low level in the time available during implantation of the donor organ.

Funder

British Heart Foundation

Publisher

SAGE Publications

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