An update on vaccines against Shigella-Reference-Cited by-同舟云学术

An update on vaccines against Shigella

Published:2013-08-09 Issue:3 Volume:1 Page:113-123
ISSN:2051-0144
Container-title:Therapeutic Advances in Vaccines
language:en
Short-container-title:Therapeutic Advances in Vaccines

Author:

Ashkenazi Shai¹,Cohen Dani²

Affiliation:

1. Department of Pediatrics A, Schneider Children’s Medical Center, 14 Kaplan Street, Petach Tikva 49202, Israel

2. School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Israel

Abstract

Despite intensive research efforts for more than 60 years, utilizing diverse vaccine strategies, a safe and efficacious vaccine against shigellosis is not available yet. We are currently witnessing innovative approaches based on elucidation of the virulence mechanisms of Shigella, understanding the immune response to the pathogen and progress in molecular technology for developing Shigella vaccines. It is hoped that these will lead to a licensed effective Shigella vaccine to protect humans against the significant worldwide morbidity and mortality caused by this microorganism.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/2051013613500428

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