Inhibition of neointimal formation and hyperplasia in vein grafts by external stent/sheath

Author:

Desai Mital1,Mirzay-Razzaz Jalaledin1,von Delft Dirk2,Sarkar Sandip3,Hamilton George4,Seifalian Alexander M5

Affiliation:

1. Centre for Nanotechnology and Regenerative Medicine, Division of Surgery & Interventional Science, University College London, London, UK, Cardiovascular Haemodynamic Group, University College London, London, UK

2. Christiaan Barnard Division of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa

3. Centre for Nanotechnology and Regenerative Medicine, Division of Surgery & Interventional Science, University College London, London, UK

4. Vascular Unit, Royal Free Hampstead NHS Trust Hospital, London, UK

5. Centre for Nanotechnology and Regenerative Medicine, Division of Surgery & Interventional Science, University College London, London, UK, Cardiovascular Haemodynamic Group, University College London, London, UK,

Abstract

Synthetic and to a lesser extent vein graft failure is still a major problem in the treatment of peripheral arterial disease, with neointimal hyperplasia being the main cause for graft occlusion in the medium and long term. This review aims to establish the current status of external stents or sheaths in the prevention of intimal hyperplasia in small diameter (< 6 mm) vein grafts.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

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