Soluble Form of Selectins in Blood of Patients with Acute Myocardial Infarction and Coronary Intervention

Abstract

Soluble (s) P-selectin, sE-selectin, sL-selectin and soluble intercellular adhesion molecule-1 (sICAM-1) levels were examined by monoclonal antibody-based enzyme immunoassay on serum samples taken from nine patients with acute myocardial infarction (AMI) and eight patients with stable angina pectoris (SAP) before and after the successful percutaneous transluminal coronary angioplasty (PTCA). In patients with acute phase of AMI, the levels (mean ± SEM) of sP-selectin (110 ± 18 ng/ml) and sE-selectin (54 ± 15 ng/ml) before PTCA, were significantly higher than those in the SAP group, the values being 44 ± 27 and 21 ± 4 ng/ml ( p<0.05), respectively. After recanalization, the levels of sE-selectin and sL-selectin were significantly decreased (sE-selectin 54 ± 15 to 42 ± 11 ng/ml, sL-selectin 1104 ± 106 to 891 ± 59 ng/ml, P < 0.05, respectively). These findings suggest that the presence of activated and/or injured endothelial cells, which may be involved in the plaque disruption or intraluminal thrombosis in AMI region and that the inflammatory process may be altered after reperfusion therapy.