Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19-Reference-Cited by-同舟云学术

Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19

Published:2024-04-04 Issue:3 Volume:9 Page:676-686
ISSN:2396-9873
Container-title:European Stroke Journal
language:en
Short-container-title:European Stroke Journal

Author:

Scutelnic Adrian¹^ORCID,van de Munckhof Anita²,Miraclin Angel T.³,Aaron Sanjith³,Hameed Sajid⁴,Wasay Mohammad⁴,Grosu Oxana⁵,Krzywicka Katarzyna²,Sánchez van Kammen Mayte²,Lindgren Erik⁶⁷,Moreira Tiago⁸⁹,Acampora Roberto¹⁰,Negro Alberto¹⁰,Karapanayiotides Theodoros¹¹,Yaghi Shadi¹²,Revert Anna¹³,Cuadrado Godia Elisa¹³,Garcia-Madrona Sebastian¹⁴,La Spina Paolino¹⁵,Grillo Francesco¹⁵,Giammello Fabrizio¹⁵^ORCID,Nguyen Thanh N.¹⁶¹⁷^ORCID,Abdalkader Mohamad¹⁷,Buture Alina¹⁸,Sofia Cotelli Maria¹⁹,Raposo Nicolas²⁰^ORCID,Tsivgoulis Georgios²¹^ORCID,Candelaresi Paolo²²^ORCID,Ciacciarelli Antonio²³²⁴^ORCID,Mbroh Joshua²⁵^ORCID,Batenkova Tatiana²⁶^ORCID,Scoppettuolo Pasquale²⁷,Zedde Marialuisa²⁸,Pascarella Rosario²⁹,Antonenko Kateryna¹,Kristoffersen Espen S.³⁰^ORCID,Kremer Hovinga Johanna A.³¹,Jood Katarina⁶⁷,Aguiar de Sousa Diana³²^ORCID,Poli Sven²⁵³³,Tatlisumak Turgut⁶⁷,Putaala Jukka³⁴,Coutinho Jonathan M.²^ORCID,Ferro José M.³⁵,Arnold Marcel¹,Heldner Mirjam R.¹

Affiliation:

1. Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

2. Department of Neurology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands

3. Department of Neurosciences, Christian Medical College Hospital, Vellore, Tamil Nadu, India

4. Aga Khan University, Karachi, Pakistan

5. Institute of Neurology and Neurosurgery “Diomid Gherman,” Chisinau, Republic of Moldova

6. Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden

7. Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden

8. Department of Neurology, Karolinska University Hospital, Stockholm, Sweden

9. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

10. Department of Neurology and Stroke Unit, Ospedale del Mare Hospital, Naples, Italy

11. 2nd Department of Neurology, Aristotle University of Thessaloniki, School of Medicine, AHEPA University Hospital, Greece

12. Department of Neurology, Brown University, Providence, RI, USA

13. Hospital del Mar, Faculty of Medicine and Life Sciences, Pompeu Fabra University Barcelona, Spain

14. Department of Neurology and Stroke Center, University Hospital Ramón y Cajal, Madrid, Spain

15. Translational Molecular Medicine and Surgery 36th Cycle, Department of BIOMORF, Stroke Unit, Department of Clinical and Experimental Medicine, University Hospital G. Martino, Messina, Italy

16. Neurology, Boston Medical Center, MA, USA

17. Radiology, Boston Medical Center, MA, USA

18. Mater Misericordiae University Hospital, Dublin, Ireland

19. Neurology Unit ASST Valcamonica, Esine, Brescia, Italy

20. Department of Neurology, University Hospital of Toulouse, Toulouse, France

21. Second Department of Neurology, National & Kapodistrian University of Athens, School of Medicine, “Attikon University Hospital”, Athens, Greece

22. Neurology and Stroke Unit, Cardarelli Hospital, Naples, Italy

23. Neurology Division, Santa Maria Goretti Hospital, Latina, Italy

24. Department of Translation and Precision Medicine, Sapienza University of Rome, Italy

25. Department of Neurology & Stroke, University Hospital Tuebingen, Eberhard-Karls University, Tuebingen, Germany

26. Sverdlovsk Regional Clinical Hospital No. 1, Yekaterinburg, Russia

27. Neurology Department, Cliniques Universitaires Saint Luc, Université Catholique de Louvain (UCL), Brussels, Belgium

28. Neurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy

29. Neuroradiology Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy

30. Department of Neurology, Akershus University Hospital, Lorenskog, Norway

31. Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

32. Lisbon Central University Hospital and Faculdade de Medicina da Universidade de Lisboa, Portugal

33. Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Tuebingen, Germany

34. Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

35. Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal

Abstract

Introduction: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT. Patients and methods: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex. Results: We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2–4] vs 2 [1–3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7–20] vs 8 [4–15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3–16] vs 7/206 [3%, 2–7], aOR 2.6 [95% CI 0.7–9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0–2; 45/58 [78%, 95% CI 65–86] vs 161/185 [87%, 81–91], aOR 0.5 [95% CI 0.2–1.02]). Conclusion: In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/23969873241241885

Reference41 articles.

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