Acute care bundles should be used for patients with intracerebral haemorrhage: An expert consensus statement

Author:

Parry-Jones Adrian R1ORCID,Järhult Susann J2,Kreitzer Natalie3,Morotti Andrea4ORCID,Toni Danilo5,Seiffge David6ORCID,Mendelow Alexander David7,Patel Hiren1,Brouwers Hens Bart8,Klijn Catharina JM9,Steiner Thorsten10ORCID,Gibler Walter Brian3,Goldstein Joshua N11

Affiliation:

1. Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance & University of Manchester, Manchester, UK

2. Department of Medical Sciences, Uppsala University, Emergency Department, Uppsala University Hospital, Uppsala, Sweden

3. Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA

4. Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy

5. Emergency Department Stroke Unit, Policlinico Umberto I, University La Sapienza Rome, Italy

6. Department of Neurology, Inselspital, University Hospital and University of Bern, Bern, Switzerland

7. Neurosurgery Trials Group, Newcastle University, Newcastle, UK

8. Department of Neurosurgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands

9. Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands

10. Departments of Neurology, Klinikum Frankfurt Höchst, Frankfurt and Heidelberg University Hospital, Heidelberg, Germany

11. Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA

Abstract

Purpose: Intracerebral haemorrhage (ICH) is the most devastating form of stroke and a major cause of disability. Clinical trials of individual therapies have failed to definitively establish a specific beneficial treatment. However, clinical trials of introducing care bundles, with multiple therapies provided in parallel, appear to clearly reduce morbidity and mortality. Currently, not enough patients receive these interventions in the acute phase. Methods: We convened an expert group to discuss best practices in ICH and to develop recommendations for bundled care that can be delivered in all settings that treat acute ICH, with a focus on European healthcare systems. Findings: In this consensus paper, we argue for widespread implementation of formalised care bundles in ICH, including specific metrics for time to treatment and criteria for the consideration of neurosurgical therapy. Discussion: There is an extraordinary opportunity to improve clinical care and clinical outcomes in this devastating disease. Substantial evidence already exists for a range of therapies that can and should be implemented now.

Funder

EMCREG-International

National Institutes of Health

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical)

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