Looking ahead: giant-cell arteritis in 10 years time

Author:

Bond Milena1ORCID,Tomelleri Alessandro2,Buttgereit Frank3,Matteson Eric L.4,Dejaco Christian56

Affiliation:

1. Department of Rheumatology, Hospital of Brunico (SABES-ASDAA), Brunico, Italy

2. Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy

3. Department of Rheumatology and Clinical Immunology, Charitè University Medicine Berlin, Berlin, Germany

4. Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA

5. Professor, Department of Rheumatology, Hospital of Brunico (SABES-ASDAA), Via Ospedale 11, 39031 Brunico, Italy

6. Department of Rheumatology and Immunology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria

Abstract

Although great improvements have been achieved in the fields of diagnosing and treating patients with giant-cell arteritis (GCA) in the last decades, several questions remain unanswered. The progressive increase in the number of older people, together with growing awareness of the disease and use of advanced diagnostic tools by healthcare professionals, foretells a possible increase in both prevalence and number of newly diagnosed patients with GCA in the coming years. A thorough clarification of pathogenetic mechanisms and a better definition of clinical subsets are the first steps toward a better understanding of the disease and, subsequently, toward a better use of existing and future therapeutic options. Examination of the role of different imaging techniques for GCA diagnosing and monitoring, optimization, and personalization of glucocorticoids and other immunosuppressive agents, further development and introduction of novel drugs, identification of prognostic factors for long-term outcomes and management of treatment discontinuation will be the central topics of the research agenda in years to come.

Publisher

SAGE Publications

Subject

Orthopedics and Sports Medicine,Rheumatology

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