Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis

Author:

FitzGerald Oliver1ORCID,Behrens Frank2,Barton Anne3,Bertheussen Heidi4,Boutouyrie-Dumont Bruno5,Coates Laura6ORCID,Davies Owen7,de Wit Maarten8ORCID,Fagni Filippo910,Goodyear Carl S.11,Gurke Robert12,Hahnefeld Lisa12ORCID,Huppertz Christine5,Ioannidis Vassilios13,Ibberson Mark13,Katz Arnon14,Klippstein Maximilian2,Koehm Michaela2,Korish Shimon15,Mackay Sina16,Martin David A.17,O’Sullivan Denis18,Patel Khadijah3,Rueping Stefan16,Schett Georg910,Scholich Klaus12,Schwenk Jochen M.19ORCID,Siebert Stefan11ORCID,Simon David910,Vivekanantham Arani6,Pennington Stephen R.1ORCID

Affiliation:

1. School of Medicine, UCD Conway Institute for Biomolecular Research, University College Dublin, Ireland

2. Translational Rheumatology, Immunology – Inflammation Medicine, University Hospital Goethe-University, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP and Fraunhofer Cluster of Excellence Immune Mediated Diseases, Frankfurt, Germany

3. Centre for Musculoskeletal Research, the University of Manchester, Manchester, UK

4. GRAPPA Patient Research Partner, Norway

5. Novartis Institutes for BioMedical Research, Basel, Switzerland

6. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK

7. UCB Pharma, Slough, UK

8. GRAPPA Patient Research Partner, Zaltbommel, the Netherlands

9. Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany

10. Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany

11. School of Infection & Immunity, College of Medical, Veterinar & Life Sciences, University of Glasgow, Glasgow, UK

12. Pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP and Fraunhofer Cluster of Excellence Immune Mediated Diseases, Frankfurt, Germany

13. Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland

14. GRAPPA Patient Research Partner, Israel

15. Bristol Myers Squibb, Princeton, NJ, USA

16. Fraunhofer Institute for Intelligent Analysis and Information Systems IAIS, Sankt Augustin and Fraunhofer Cluster of Excellence Immune Mediated Diseases, Frankfurt, Germany

17. Pfizer Immunology & Inflammation Research Unit, Cambridge, MA, USA

18. GRAPPA Patient Research Partner, Ireland

19. Affinity Proteomics, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden

Abstract

Achieving a good outcome for a person with Psoriatic Arthritis (PsA) is made difficult by late diagnosis, heterogenous clinical disease expression and in many cases, failure to adequately suppress inflammatory disease features. Single-centre studies have certainly contributed to our understanding of disease pathogenesis, but to adequately address the major areas of unmet need, multi-partner, collaborative research programmes are now required. HIPPOCRATES is a 5-year, Innovative Medicines Initiative (IMI) programme which includes 17 European academic centres experienced in PsA research, 5 pharmaceutical industry partners, 3 small-/medium-sized industry partners and 2 patient-representative organizations. In this review, the ambitious programme of work to be undertaken by HIPPOCRATES is outlined and common approaches and challenges are identified. It is expected that, when completed, the results will ultimately allow for changes in the approaches to diagnosing, managing and treating PsA allowing for better short-term and long-term outcomes.

Publisher

SAGE Publications

Subject

Orthopedics and Sports Medicine,Rheumatology

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