Association Between Severity of COVID-19 Respiratory Disease and Risk of Obstructive Sleep Apnea-Reference-Cited by-同舟云学术

Association Between Severity of COVID-19 Respiratory Disease and Risk of Obstructive Sleep Apnea

Published:2021-07-28 Issue: Volume: Page:014556132110297
ISSN:0145-5613
Container-title:Ear, Nose & Throat Journal
language:en
Short-container-title:Ear Nose Throat J

Author:

Iannella Giannicola¹,Vicini Claudio¹²,Lechien Jerome R.³,Ravaglia Claudia⁴,Poletti Venerino⁴⁵,di Cesare Simona⁶,Amicarelli Elena⁶,Gardelli Lucia⁶,Grosso Carmela⁷,Patacca Aria⁷,Magistrelli Eleonora⁷,De Benedetto Michele⁸,Toraldo Domenico Maurizio⁹,Arigliani Michele⁸,Cammaroto Giovanni²,Meccariello Giuseppe²,De Vito Andrea¹⁰,Magliulo Giuseppe¹¹^ORCID,Greco Antonio¹¹,de Vincentiis Marco¹¹,Ralli Massimo¹¹,Pace Annalisa¹¹,Montincone Valentina¹²,Maniaci Antonino¹³^ORCID,Cocuzza Salvatore¹³,Seligardi Matteo¹⁴,di Giacinto Ida¹⁵^ORCID,Corso Ruggero Massimo¹⁶

Affiliation:

1. Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Forlì, Italy

2. Department of ENT & Audiology, University of Ferrara, Ferrara, Italy

3. Faculty of Medicine, Laboratory of Anatomy and Cell Biology, University of Mons (UMONS), Mons, Belgium

4. Pulmonology Unit, Thoracic Diseases Department, G.B. Morgagni Hospital, Forlì, Italy

5. Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark

6. Medicine Department, G.B. Morgagni Hospital, Forlì, Italy

7. Department of Infectious Diseases, G.B. Morgagni Hospital, Forlì, Italy

8. ENT Unit, “V. Fazzi” Hospital, ASL Lecce, Italy

9. Hospital Rehabilitation Department, Cardio-Respiratory Care Unit, “V. Fazzi”, ASL Lecce, Italy

10. Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Ospedale “Santa Maria delle Croci”, Viale Vincenzo Randi, Ravenna, Italy

11. Department of “Organi di Senso,” University “Sapienza,” Rome, Italy

12. Otolaryngology Department, Azienda Sanitaria Locale CN2, Alba, Italy

13. Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia,” ENT Section, University of Catania, Catania, Italy

14. Infectious Disease Unit, Azienda Unità Sanitaria Locale – IRCCS di Reggio, Emilia, Italy

15. Anesthesia and Intensive Care, Anestesia e Terapia Intensiva Polivalente, Azienda Ospedaliero-Universitaria, Sant’Orsola-Malpighi – Alma Mater Studiorum, Bologna, Italy

16. Intensive Care Unit, Morgagni-Pierantoni Hospital, AUSL of Romagna, Forlì, Italy

Abstract

Objectives: The purpose of this observational retrospective study was to evaluate, in patients with a severe acute respiratory syndrome coronavirus 2 infection, the association between the severity of coronavirus disease 2019 (COVID-19) respiratory illness and the risk of infected patients to develop obstructive sleep apnea (OSA). Methods: Ninety-six patients with confirmed COVID-19 infection were enrolled in the study. The STOP-BANG questionnaire to investigate the risk of the OSA syndrome was filled in by the patients at admission. The enrolled patients were divided into 2 groups according to the respiratory disease: group 1 (72 patients), hospitalized patients undergoing conventional oxygen therapy; group 2 (24 patients), patients requiring enhanced respiratory support. STOP-BANG results of these 2 groups were compared to observe whether patients with high OSA risk more frequently presented a severe form of COVID-19. Results: 41.6% of the patients in group 2 had a STOP-BANG score between 5 and 8 (high risk of having apnea); in contrast, 20.8% of the patients in group 1 had a STOP-BANG score between 5 and 8, with a statistically significant difference between the 2 groups ( P = .05). A complementary trend was observed regarding the proportion of patients in the range 0 to 2, which classifies patients at a low risk of OSA (48.6% vs 20.8% for groups 1 and 2, P = .01). Conclusions: According to our data, the chances of having a severe case of COVID-19 should be considered in patients at high risk of OSA. Current Knowledge/Study Rationale: Emerging research suggests that OSA could represent a potentially important risk factor for the severe forms of COVID-19. The purpose of this observational retrospective study was to evaluate the potential association between OSA and the severity of COVID-19 disease. Study Impact: According to our data, the likelihood of contracting a severe form of COVID-19 disease should be considered in patients at high risk of OSA.

Publisher

SAGE Publications

Subject

Otorhinolaryngology

Link

http://journals.sagepub.com/doi/pdf/10.1177/01455613211029783

Reference31 articles.

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