Changing Trends of Color of Different Laryngeal Regions in Laryngopharyngeal Reflux Disease

Author:

Du Chen1,Thayer Paige2,Yan Yan1ORCID,Liu Qingsong1,Wang Li1,Jiang Jack2

Affiliation:

1. Department of Otolaryngology, Peking University Third Hospital, Beijing, People’s Republic of China

2. Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

Abstract

Introduction: In our previous study, we demonstrated that there might be correlations between laryngopharyngeal reflux disorder and the hue value of laryngoscopic images. And we found that different regions of larynx have different hue values. It was hypothesized that the degree of inflammation varies between different laryngeal regions, due to an acid reflux pattern. Objective: The objective of this study was to compare the changing trends of hue values of different laryngeal regions in patients with laryngopharyngeal reflux (LPR) disease. Methods: Ninety-seven patients, including 20 pH-positive, 19 pH-negative were tested for LPR through multichannel intraluminal impedance 24-hour pH monitoring, and 58 controls with reflux symptom index less than 13. Laryngoscopic images of all patients were obtained. The hue values of 7 areas of interest, including both sides of the true vocal folds, the false vocal folds, the arytenoids, and the interarytenoid space, were quantified using a hue calculation. The analysis of variance analysis was applied to find if there was significant difference between different groups within each region. Results: (1) In the regions of both sides of the true vocal folds and interarytenoid, there was no significant difference between positive group and negative group; (2) in the regions of both sides of false vocal folds, there was no significant difference between negative group and control group; (3) in the regions of both sides of arytenoids, there was neither significant difference between positive group and negative group nor between negative group and control group; (4) in other comparisons, there were significant differences. Conclusion: Hue values of separate laryngeal regions are different. In negative group, the hue values of interarytenoid region are similar with positive group, and the sensitivity to the acid are different from different regions. The sensitivity in the true vocal folds may be present.

Funder

Returned Oversea Visiting Scholars Setup Funding of PUTH

Publisher

SAGE Publications

Subject

Otorhinolaryngology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The Differences between Gastroesophageal and Laryngopharyngeal Reflux;Gastroesophageal Reflux Disease - A Growing Concern [Working Title];2022-08-22

2. Production, characterization and shelf-life evaluation of Caryocar brasiliense pulp flour;International Journal of Gastronomy and Food Science;2022-06

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