Efficient Monte Carlo evaluation of resampling-based hypothesis tests with applications to genetic epidemiology

Abstract

Monte Carlo evaluation of resampling-based tests is often conducted in statistical analysis. However, this procedure is generally computationally intensive. The pooling resampling-based method has been developed to reduce the computational burden but the validity of the method has not been studied before. In this article, we first investigate the asymptotic properties of the pooling resampling-based method and then propose a novel Monte Carlo evaluation procedure namely the n-times pooling resampling-based method. Theorems as well as simulations show that the proposed method can give smaller or comparable root mean squared errors and bias with much less computing time, thus can be strongly recommended especially for evaluating highly computationally intensive hypothesis testing procedures in genetic epidemiology.